The critical role played by the basal ganglia in the pathogenesis of
various movement disorders such as Parkinson's and Huntington's
diseases has been known for many years.
Recent studies have indicated that the neural networks of the basal
ganglia participate in everyday complex behaviors that require
coordination between cognition, motivation and movements.
Our research is therefore aimed at both directions. First, we try to
provide better understanding of the role and way of action of the
basal ganglia-cortical networks in normal behavior, and secondly we
are studying these networks following the induction of clinical
disorders such as Parkinson's disease and dyskinesia.
Our group is the only group worldwide that has been able to record
the simultaneous activity of several neurons in the basal ganglia of
awake, normal, Parkinsonian and dyskinetic monkeys and to combine
this data with insights from the field of neural networks and
computational neuroscience. Our belief is that only through such
broad and interdisciplinary understanding we will be able to provide
better methods for diagnosis, follow-up and therapy of these common
devastating human diseases.
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Bergman H., Wichmann T. and DeLong M.R. Reversal of Experimental Parkinsonism by
Lesions of the Subthalamic Nucleus. Science. 249: 1436-1438, 1990
Nini A, Feingold A, Slovin H and Bergman H.
Neurons in the globus pallidus do not show correlated activity in the normal
monkey, but phase-locked oscillations appear in the MPTP model of parkinsonism.
J. of Neurophysiology, 74(4):1800-5, 1995
A. Raz, E. Vaadia and H. Bergman. Firing patterns and correlations of
spontaneous discharge of pallidal neurons in the normal and tremulous MPTP
Vervet model of Parkinsonism. J. of Neuroscience, 20(22): 8559-8571, 2000
Izhar Bar-Gad, Genela Morris and Hagai Bergman, Information processing,
dimensionality reduction and reinforcement learning in the basal ganglia;
Progress in Neurobiology, 71(6): 439-473, 2003
Genela Morris, David Arkadir, Alon Nevet, Eilon Vaadia and Hagai Bergman,
Coincident but distinct messages of midbrain dopamine and striatal tonically
active neurons, Neuron, 43: 133-143, 2004
Joshua M, Adler A, Prut Y, Vaadia E, Wickens JR and Bergman H
Synchronization of midbrain dopaminergic neurons is enhanced by rewarding events.
Neuron. 62:695-704, 2009.
Zaidel, A, Spivak A, Grieb B, Bergman H, Israel Z.
Subthalamic span of beta oscillations predicts deep brain stimulation efficacy for patients with Parkinson's disease.
Brain. 133:2007-21, 2010
Boris Rosin, Maya Slovik, Rea Mitelman, Michal Rivlin-Etzion, Suzanne N. Haber, Zvi Israel, Eilon Vaadia and Hagai Bergman.
Closed-Loop Deep Brain Stimulation Is Superior in Ameliorating Parkinsonism.
Neuron. 72(2):370-384, 2011.
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