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I started to look into basal ganglia physiology and the
pathophysiological mechanisms of Parkinson's disease in 1988, during
my post-doctoral fellowship with Mahlon DeLong at the Johns Hopkins
Hospital, Baltimore, Maryland, USA (1987-1990). Here, in the
Department of Physiology of the Hebrew university – Hadassah medical
school, Jerusalem, I was able to combine the two different domains
of my post-doctoral fellowships. Since 1990, I am employing combined
behavioral, multi-electrode physiological and computational
approaches to probe the relations between the basal ganglia - cortex
networks and normal and pathological behavior. We are recording the
simultaneous activity of several neurons in different structures of
the basal ganglia of monkeys that are engaged in the performance of
behavioral tasks that involve visual perception, probabilistic
decision making and motor action. Moreover, we were able to study
the neural activity following the induction of Parkinson’s disease
(with the MPTP neurotoxin) and following dopamine induced dyskinesia,
both in the MPTP and control (MPTP-naïve) monkeys.
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